. 1
( 2 .)



>>

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e?OUEIIUEI «‚AIOAIO„O
U?OI·O?I·OIEAI»
IEAIOIOIAIUI??I?IE „AO?EIIE:
IAOUO i?„IEI
A.a. oEIO‚
e?OUAOOO?
aaA EIAIE a.a. eA?AIO‚

aiiciue o?iiaiyiaieeci» (a nia?aiaiiie ia?- ?ei–iiiiia?iuo eiiieaenia), ?oi aaaao e enoiuaie?
«A aoia?iaiie eeeie?aneie o?aeoiaea) – caaieaaa- aeoeaiinoe aioeeiaaoeyioiuo eiiiiiaioia e?iae e oa-
iea, iauaaeiy?uaa a naaa aaa iaoieiae?aneeo i?ioan- iaoaie? oea?eiieeca. Nia?aiaiiia ea?aiea e i?ioe-
na: 1) ainiaeaiea aeoaieeo aai ie?ieo eiia?iinoae e eaeoeea na?aa?ii–ninoaenouo inei?iaiee iaaicii?iu
iaeiai oaca n oi?ie?iaaieai o?iiaia ia noaiea (OAA), aac ?aoeiai i?aanoaaeaiey iaoaieciia o?iiaiia?aci-
n no?aieai eee «caeoii?eie» eo i?inaaoa e a ?acoeuoa- aaiey, iaoa?eaeuiui noano?aoii eioi?iai yaey?ony
oa – ?inoa o?iiaa; 2) o?aaiaioaoey o?iiaia e ia?aia- oea?ei, o?iiaioeou, y?eo?ioeou (?en. 1).
uaiea aai o?aaiaioia aenoaeuiaa e?iaioiea – o?iiai- A ianoiyuaa a?aiy a eeeie?aneie i?aeoeea n oaeu?
yiaieey (a ?anoiinoe, o?iiaiyiaieey aaoaae eaai?iie i?ioeeaeoeee e ea?aiey o?iiaiyiaiee?aneeo inei?ia-
iee eniieuco?o 4 eeanna aioeo?iiaioe?aneeo i?aia-
a?oa?ee).
?aoia: 1 – i?yiua aioeeiaaoeyiou (aaia?ei, ieceiiiea-
A iaoiaaiaca OAA ee??aao? ?ieu i?eieia?o o?e
i?ioanna, ii?aaaeyaiuo eae o?eaaa Ae?oiaa: iia?a?- eoey?iua aaia?eiu); 2 – iai?yiua aioeeiaaoeyiou (ei-
aaiea yiaioaeey (ainiaeaiea); caiaaeaiea aaiiciiai aeaeoi?u o?iiaeia, aicaaenoao?uea ia aeoaiei E–ca-
e?iaioiea (canoie); iiauoaiea eiaaoeyoeiiiiai iioai- aeneiua oaeoi?u naa?ouaaiey); 3 – aioeaa?aaaiou
oeaea e?iae. Iiaoaeoaeuiuie iiiaioaie a ?acaeoee (i?aia?aou, aicaaenoao?uea ia aaaace? e aa?aaaoe?
o?eaau Ae?oiaa yaey?ony ?acee?iua caaieaaaiey, ni- o?iiaioeoia – ianoa?ieaiua i?ioeaiainiaeeoaeuiua
i?iai?aa?ueany aeeoaeuiui aeiieeiacii (iinoaeuiue i?aia?aou, eeiieaia?ae), 4 – o?iiaieeoe?aneea i?a-
?a?ei), ainiaeeoaeuiie ?aaeoeae i?aaiecia, ia?ooa- ia?aou (n?aanoaa, aeoeae?o?uea oea?eiieeoe?aneo?
ieyie e?iaioiea. I?e ainiaeeoaeuiii e aoa?ineea?ioe- nenoaio ?a?ac i?aia?aciaaiea ieacieiiaaia a ieaciei)
?aneii iia?a?aaiee yiaioaeey ninoaia ?acee?iie ei- [1–11].
eaeecaoee eia?o ianoi ?aaeiia?iua e nenoaiiua ecia- O?aaeoeiiii a noaoeiia?ao n oaeu? i?aaoi?a?aa-
iey o?iiaicia eniieuco?o aaia?eiioa?aie?. Aaia?ei
iaiey eiaaoeyoeiiiiai iioaioeaea e?iae a noi?iio ae-
ia?eiaaoeyoee ca n?ao iiauoaiey aa?aaaoeiiiie e aa- yaeyaony iniiaiui i?aia?aoii aey ea?aiey OAA e OY,
aaceaiie aeoeaiinoe o?iiaioeoia e y?eo?ioeoia, aeoe- ii iiaaaeyao ?ino o?iiaia, niinianoaoy eo eeceno, i?a-
aaoee ieaciaiiuo eiaaoeyoeiiiuo oaeoi?ia (oea?eii- aoi?a?aaao aaia?aeecaoe? o?iiaioe?aneiai i?ioanna e
aai, oea?einoaaeeece?o?uee oaeoi?, iiyaeaiea oea- iiaoi?iua yieciau OY.
Aaia?ei – «i?yiie» aioeeiaaoeyio aia?aua aue
EIAAOE?OE? auaaeai a 1916 aiao ec ia?aie (ii?aaaeeaoae aai
iacaaiea), a oa?iaeieiae?aneie i?iiuoeaiiinoe
iieo?a?o ec eaaeeo e?oiiiai ?iaaoiai neioa. Aaia-
?ei ii naiae oeie?aneie i?e?iaa yaeyaony aeeeica-
Aaia?ei
ieiiaeeeaiii, i?iaooe?oaony eeaoeaie ?acee?iuo
+ AOIII
i?aaiia ?aeiaaea e ?eaioiuo, ieacuaaao eiaeae?o-
IA
AIOA ?uaa aaenoaea ia naa?ouaa?uo? nenoaio e?iae eae
in vivo, oae e in vitro. A ianoiyuaa a?aiy a eeeie?a-
neie i?aeoeea aaia?ei i?aanoaaeai a aeaa aaoo aa-
?eaioia: eeanne?aneee iao?aeoeiie?iaaiiue aaia-
OA IIA ?ei (IOA) e a?oiia i?aia?aoia o?aeoeiie?iaaiii-
ai eee ieceiiieaeoey?iiai aaia?eia (IIA) [5].
IOA – eiiiiceoiue i?aia?ao, niaa??auee
o?aeoee n ?aciie aeeiie iieeia?iie oaie, ii?aaa-
ey?uea ?aciiiieaeoey?iinou iannu (io 3000 ai
40000 aaeuoii) aeieiae?anee aeoeaiuo aauanoa.
IOA naycuaaynu n AOIII, aeoeaece?oao aai e aeiee?o-
OEA?EIIEEC ao o?iiaiia?aciaaiea ia ?acee?iuo yoaiao naa?ou-
aa?uae nenoaiu e?iae, ?oi e ii?aaaeeei oa?aeoa-
?en. 1. Noaia eiaaoeyoeiiiuo e oea?eiieeoe?aneiai eaneaaia
e?iae, oi?ee i?eei?aiey iao?aeoeiiiiai e ieceiiieaeoey?iiai ?enoeeo IOA, eae «i?yiiai» aioeeiaaoeyioa. Eiae-
aaia?eiia
ae?ouay aeoeaiinou AOIII i?e aaaaaiee IOA aic?an-


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?ecoaony oai, ?oi aaco?iiaioeoa?iay ieacia iaoeaioa
oaao a 1000 ?ac. Iniiaie aioeeiaaoeyoeiiiiai yooaeoa
i?e aiaaaeaiee aaia?eia aucuaaao aa?aaaoe? naieo e
yaeyaony ia?aciaaiea o?ieiuo eiiieaenia: [IOA + AOIII
aiii?neeo o?iiaioeoia.
+ IIa] e [IOA + AOIII + Xa]. I?iyaeaiea aioeeiaaoeyioiie
AEO ?anoi ni?aoaaony n aaiiciui e a?oa?eaeuiui
aeoeaiinoe IOA aicii?ii oieuei i?e ii?iaeuiii o?ia-
o?iiaicii, ?aaeiia?iui e nenoaiiui AAN–neia?iiii,
ia AOIII. A neo?ayo iiauoaiiiai iio?aaeaiey AOIII, aaao-
ia?ooaieyie iicaiaiai e ei?iia?iiai e?iaiia?aua-
uaai e nie?aie? aai eiioaio?aoee a e?iae (AAN–nei-
iey. AEO ?aua (io 2 ai 10% i?e aaia?eiioa?aiee) ?ac-
a?ii, ianneaiia o?iiaiia?aciaaiea), aaaaaiea aaia-
aeaaaony i?e eniieuciaaiee naeiiai aaia?eia [7]. Yoi
?eia ia yooaeoeaii aac aiciauaiey iioa?u AOIII. I?e
ii?ao auou naycaii n iia?a?aaieai yiaioaeeaeuiuo
naycuaaiee IOA n AOIII i?ienoiayo eiioi?iaoeiiiua
eeaoie e yeni?anneae oeaiaaiai oaeoi?a aaia?ei–eiao-
eciaiaiey a iieaeoea iineaaiaai, niinianoao?uea on-
oe?iaaiiuie IgG–aioeoaeaie, i?yiie aeoeaaoeae
ei?aie? eiiieaeniiai ia?aciaaiey AOIII n na?ei–i?ioa-
o?iiaioeoia aaia?eiii, iaeo?aeecaoeae aaia?eia in-
acaie nenoaiu eiaaoeyoee. A ?acoeuoaoa aeiee?o?ony
aiai?aa?ueiny ec o?iiaioeoia FIV (aioeaaia?eiiaue
o?iiaei, oa?iaioaoeaiay aeoeaiinou aeoeae?iaaiiuo
oaeoi?).
oaeoi?ia IX, X, XI, XII, ieacieia e eaeeee?aeia.
Aaenoaea IOA eiaeaeaoaeuii o ea?aiai iaoeaioa,
I?e aeiee?iaaiee aeoeaiinoe o?iiaeia eiiieaenii
iaoneiaeaii o?iaiai AOIII e niiniaiinou? naycuaaiey
IOA + AOIII eiaeae?oaony ?ya eiaaoeyoeiiuo yooaeoia:
aaia?eia n aaeeaie ieaciu, ?oi o?aaoao ouaoaeuiiai
nie?a?ony o?iaie FI, FII, FV, FVII, FXIII, aa?aaaoeiiiay
eaai?aoi?iiai eiio?iey eiaaoeyoeiiiuo iieacaoaeae
aeoeaiinou e eiee?anoai o?iiaioeoia.
e?iae e eiee?anoaa o?iiaioeoia. IOA aaenoaoao auno?i,
Iaiaiicia?ii aaenoaea iao?aeoeiiiiai aaia?eia
ii e?aoeia?aiaiii, iaoaaieece?oaony ia?aiu? e auai-
ia o?iiaioeoa?iia caaii: ?ya enneaaiaaoaeae oeacuaa-
aeony ii?eaie. I?e aica 100 AA/ea aeieiae?aneee ia?e-
?o ia aioeaa?aaaoeiiiia aaenoaea ca n?ao aioeo?iiae-
ia iieo?aniaaa ieiei 1–ai ?ana. I?e iiaei?iii aaaaa-
iiaie aeoeaiinoe e oaaee?aiey io?eoaoaeuiiai ca?yaa
iee IOA n oaeu? i?ioeeaeoeee o?iiaiia?aciaaiey a
o?iiaioeoia e y?eo?ioeoia [8], a?oaea aaoi?u ioia?a?o
aica io 1000–1500 AA/?an aeiieiaaoeyoeiiiue yooaeo
i?yii i?ioeaiiiei?iue yooaeo IOA – oaaee?aiea aa-
ianooiaao ?a?ac 40–60 ieioo e i?iaie?aaony 8–12 ?ania.
?aaaoee o?iiaioeoia ca n?ao aeoeaaoee aeeeii?ioaeii-
A?oaay ?aciiaeaiinou aaia?eia – o?aeoeiie?iaai-
auo ?aoaioi?ia GP IIb/IIIa [1,2,4]. Aaia?ei ia?acoao eii-
iue eee ieceiiieaeoey?iue (IIA) n iieaeoey?iie ian-
ieaen n o?iiaioeoa?iui FIV, e eioi?iio iiaoo ia?aci-
nie io 4000 ai 8000 aaeuoii. Iaoaieci aaenoaey IIA
auaaouny aioeoaea n iineaao?uae aeoeaaoeae aa?aaa-
ioee?aaony io aaenoaey IOA oai, ?oi yoe i?aia?aou ia-
oee o?iiaioeoia e nie?aieai eo eiee?anoaa (iaiuoa
eaaa?o aunieie aeoeaiinou? a ioiioaiee FOa, i?aeoe-
150000) (?en. 2).
?anee ia ieacuaay eiaeae?o?uaai aaenoaey ia o?iiaei
Aaia?ei–eiaooe?iaaiiay o?iiaioeoiiaiey (AEO)
(FIIa). Aneaanoaea aieaa ei?ioeie oaie IIA ia iiaoo
eiaao aaa ?aciiaeaiinoe: I – ?aiiyy oia?aiiay AEO,
oi?ie?iaaou eiiieaen [IOA + AOIII + IIa]. Ca n?ao i?ae-
?acaeaaaony iinea ia?auo eiuaeoee aaia?eia n iiau-
iouanoaaiiiai aeiee?iaaiey FOa, eioi?ue i?eieiaao
oaieai aa?aaaoeiiiie aeoeaiinoe o?iiaioeoia; II –
o?anoea ia ?aiieo noaaeyo o?iiaiia?aciaaiey, IIA
iicaiyy eiioiiay AEO (ia 7–12 aaiu ea?aiey), oa?aeoa-
eia?o ?ya i?aeiouanoa ia?aa IOA (oaae. 1), iniia-
iua ec eioi?uo :
1 – aieuoay noaaeeuiinou aeieiae?aneeo naienoa e
aeiainooiiinou (ii aioe–Oa–aeoeaiinoe);
2 – aunieay aioeo?iiaioe?aneay aeoeaiinou i?e
iaiuoai ?enea ?acaeoey e?iaioa?aiee;
3 – ionoonoaea nouanoaaiiiai aeeyiey ia o?iaaiu
aioeo?iiaeia III;
4 – i?ieiiae?iaaiiia aaenoaea n aicii?iinou?
aaaaaiey 1–2 ?aca a nooee;
5 – noeioee?o?uaa aeeyiea ia o?iiaioeou ieie-
iaeuii e ?acaeoea oo?iiaioeoiiaiee i?aeoe?anee io-
noonoaoao;
6 – aunieay yooaeoeaiinou i?eiaiaiey a oeene?i-
aaiiuo aicao, ?oi enee??aao iaiaoiaeiinou iiaai?a
aicu ii eaai?aoi?iui enneaaiaaieyi e i?iaaaaiea ea-
ai?aoi?iiai iiieoi?eiaa.
Oaaeeoa 1. N?aaieoaeuiay oa?aeoa?enoeea
IOA e IIA

Aeieiae?aneay aeoeaiinou 30% 90%
?anoioa aaaaaiey 4–6 ?ac Iaeneiaeuii – 2 ?aca
Eaai?aoi?iue eiio?ieu Iaycaoaeai Ia iaycaoaeai
?en. 2. Noaia aeoeaaoee, aa?aaaoee e aaaacee o?iiaioeoia,
aicii?iua iaoaieciu aaia?ei–eiaooe?iaaiiie O?iiaioeoiiaiee + –
o?iiaioeoiiaiee Ia?eia iieo?aniaaa 50–60 iei 1,5 – 4,5 ?ana


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A ianoiyuaa a?aiy a eeeie?aneie i?aeoeea n oaeu? ?o?aeae, e o aieuiuo oa?aiaaoe?aneeo noaoeiia?ia n
i?ioeeaeoeee e ea?aiey OAA e eo inei?iaiee eniieuco- aeeoaeuiui iinoaeuiui ?a?eiii;
aony ieiei 10 iaeiaiiaaiee IIA (neaaoao ioiaoeou, ?oi – aunieee o?iiaiyiaiee?aneee ?ene o iaoe?o?ae?a-
IIA ia yaey?ony acaeiicaiaiyaiuie). Aeoeaiinou neeo aieuiuo (ino?ay auoaoaeuiay iaainoaoi?iinou
i?aia?aoia ii?aaaeyaony eo niiniaiinou? e aeiee?iaa- e/eee ?anie?aoi?iua eioaeoee a ni?aoaiee n ino?ie
ie? oaeoi?a O–aeoeaiiai – aioe–Oa aeoeaiinou ii Ia- na?aa?iie iaainoaoi?iinou?) a oneiaeyo oa?aiaaoe?a-
?aoia?iaiiio noaiaa?oo ieceiiieaeoey?iuo aaia?e- neie ?aaieiaoee e a aeieao eioaineaiie oa?aiee;
iia. Ea?aue ec ieo eiaao naie oieeaeuiue niaeo? aioe- – ea?aiea o?iiaiyiaiee?aneeo inei?iaiee;
o?iiaioe?aneiai aaenoaey, ?oi ii?aaaeyao i?ioeeu – ino?ue ei?iia?iue neia?ii, ino?ue eioa?eo ie-
eeeie?aneie yooaeoeaiinoe [12]. iea?aa.
?aaeia?ei iao?ey – iaii?aciaue oi?eo ia 0,25 ie,
A ?innee ca?aaeno?e?iaaiu e i?eiaiy?ony iaa?i-
ia?ei, yiienaia?ei, O?aaiei (aaeoaia?ei), ?aaeia?ei. niaa??eo ?aaeia?ei iao?ey 10,4 ia aey iiaei?iiai aaa-
N?aaieoaeuiay oa?aeoa?enoeea iieacaoaeae niioiioa- aaiey, ?oi niioaaonoaoao 1750 IA aioe–Oa aeoeaiinoe, n
iee aeoeaiinoe i?ioea oaeoi?a Oa e aeoeaiinoe i?ioea n?aaiae iieaeoey?iie iannie ae?eicaieiiaeeeaiiaie
oaeoi?a IIa o i?aia?aoia IIA ?acee?ia: yiienaia?ei – oaii?ee 3500–4500 aaeuoii. Aeiainooiiinou – 90%.
3,9/1; iaa?iia?ei – 3,5/1; O?aaiei – 2,2/1. Oa?iaeieeiaoeea: eeeaa?ei, iaeaaay au?a?aiiie
Yiienaia?ei iao?ee – aiaiue ?anoai? aey eiu- aioe–oaeoi? Oa–aeoeaiinou?, aaenoaoao i?a?aa anaai
aeoee 100ia/ie. Auioneaaony a aioiauo e oiio?aaea- ia i?aaaa?eoaeuio? oaco naa?ouaaiey e?iae.
ie? oi?eoao ii 0,2; 0,4; 0,6; 0,8 e 1,0 ie (1 ia yiiena- Iniiaiua iieacaiey e iacia?aie?: aey ia?ae?iie
ia?eia niioaaonoaoao 100 aioe–Oa–AA). N?aaiyy ii- i?ioeeaeoeee o?iiaicia aeoaieeo aai o oe?o?ae?aneeo
eaeoey?iay ianna ae?eicaieiiaeeeaiiaie oaii?ee – aieuiuo a ai e iineaiia?aoeiiiii ia?eiaa a oa?aiea 7
4500 aaeuoii. aiae.
O?aaiei (aaeoaia?ei iao?ee) – iaiiaiciaue oi?eo
Oa?iaeieeiaoeea: i?e i/e aaaaaiee i?aia?ao auno-
?i e i?aeoe?anee iieiinou? ananuaaaony, iee aeoeaii- n 0,2 ie ?anoai?a aey iiaei?iie eiuaeoee niaa??eo
noe a ieacia e?iae i?e aaaaaiee 40 ia ?acaeaaaony ?a- aaeoaia?eia iao?ey 2500 eee 5000 IA aioe–Oa, 1 aiio-
?ac 3 ?ana, iaeneiaeuiay eiioaio?aoey – 1,6 iea/ie, ia- ea n 1 ie ?anoai?a aey eiuaeoee – 10 000 IA aioe–Oa.
?eia iieoauaaaaiey – ieiei 4 ?ania. O ii?eeuo eeo e Oa?iaeieeiaoeea: ia?eia iieoauaaaaiey iinea a/a
iaoeaioia n ii?a?iie iaainoaoi?iinou? ia?eia iieo- aaaaaiey i?aia?aoa – 2 ?ana, i?e iiaei?iie eiuaeoee
auaaaaiey aieaa i?iaie?eoaeai – 6–7 ?ania, ii ei?- – 3–5 ?ania. Oa?iaeieeiaoe?aneea naienoaa ia caaenyo
?aeoey aice?iaee i?aia?aoa ia o?aaoaony. Aioe–Oa–ae- io aicu, i?aia?ao auaiaeony aeaaiui ia?acii ?a?ac
oeaiinou nio?aiyaony a e?iae a oa?aiea 24 ?ania iinea ii?ee, ?oi oaaee?eaaao ia?eia iieoauaaaaiey o iaoe-
iaiie?aoiie eiuaeoee. Aeiainooiiinou i?e iiaei?iii aioia n o?aieae. Aeiainooiiinou iinea iiaei?iiai aa-
aaaaaiee – 90%. aaiey 90%.
Iniiaiua iieacaiey e iacia?aie?: Iniiaiua iieacaiey e iacia?aie?:
– i?ioeeaeoeea aaiiciuo o?iiaicia e o?iiaiyiai- – ea?aiea o?iiaica aeoaieeo aai e o?iiaiyiaieee
eee o aieuiuo n ONI: i?e iiaaioiaea e iia?aoeaiui eaai?iie a?oa?ee;
aiaoaoaeunoaai; – i?ioeeaeoeea o?iiaiia?aciaaiey i?e oe?o?ae?a-
– ea?aiea OAA a ni?aoaiee n OYEA eee aac iaa; neeo aiaoaoaeunoaao;
– ea?aiea ianoaaeeuiie noaiiea?aee e EI aac coaoa Q; – i?ioeeaeoeea naa?ouaaiey e?iae a nenoaia
– i?ioeeaeoeea eiaaoeyoee a nenoaia yeno?aei?ii- yeno?aei?ii?aeuiiai e?iaiia?auaiey ai a?aiy ieac-
?aeuiiai e?iaiia?auaiey (i?e i?iaaaaiee ieaciioa- iioa?aca, aaiiaeaeeca eee aaiioeeuo?aoee o aieuiuo
?aca, aaiiaeaeeca). n ino?ie eee o?iie?aneie ii?a?iie iaainoaoi?iinou?.
Iaa?iia?ei eaeuoey – ?anoai? aey eiuaeoee a – ianoaaeeuiay noaiiea?aey e eioa?eo ieiea?aa
i?aaaa?eoaeuii iaiieiaiiuo oi?eoao, aioiauo aey en- aac coaoa Q ia YEA.
I?ioeaiiieacaieyie e iacia?aie? IIA yaey-
iieuciaaiey. A 1 ie eiuaeoeiiiiai ?anoai?a niaa??eo-
?ony:
ny 9500 IA aioe–Oa eaeuoey iaa?iia?eia. Iauai oi?e-
oia – 0,3; 0,6; 0,8 e 1.0 ie n niaa??aieai 2850–5700 – – aaii??aae?aneee neia?ii e?aie yoeieiaee;
7600–9500 IA aioe–Oa aeoeaiinoe niioaaonoaaiii. – iaeiio?iee?oaiay oy?aeay a?oa?eaeuiay aeia?-
N?aaiyy iieaeoey?iay ianna ae?eicaieiiaeeeaiiaie oiiey;
oaii?ee – 4300 aaeuoii. – ycaaiiay aieaciu eee iiooieu ?aeoai?ii–eeoa?-
Oa?iaeieeiaoeea: aioeeiaaoeyoeiiiia aaenoaea iiai o?aeoa n aunieei ?eneii ?acaeoey e?iaioa?aiee;
o?aeneia?eia ?a?ac naycuaaiea Oa–oaeoi?a naa?ouaa-
Oaaeeoa 2. ?anoioa aaiiciuo o?iiaicia
iey; iaeneiaeuiue o?iaaiu a ieacia e?iae iinea iia- aeoaieeo aai e o?iiaiyiaieee
ei?iie eiuaeoee ainoeaaaony ?a?ac 4–6 ?ania, ia?eia a caaeneiinoe io eaoaai?ee ?enea aieuiuo
iieoauaaaaiey i?e i?eiaiaiee iiaoi?iuo aic – 8–10


?ania, aioe–Oa aeoeaiinou nio?aiyaony aieaa 18 ?ania ,

iinea aaaaaiey i?aia?aoa. Aeiainooiiinou – 98%. % , % , %
Iniiaiua iieacaiey e iacia?aie?: Ieceee < 10 <1 < 0,1
– i?ioeeaeoeea o?iiaicia e o?iiaiyiaiee?aneeo Oia?aiiue 10–40 1–10 0,1–1
Aunieee 40–80 10–30 >1
inei?iaiee, iniaaiii oao, eioi?ua naycaiu n iauae oe-


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13, 7, 2005
oOaeCOa a aOaAeeiCe
9 iaoeaioia (75%) ia 3 nooee io ia?aea ea?aiey, oaiaea-
– eioaeoeiiiue yiaiea?aeo;
oai?eoaeuiua ?acoeuoaou (nie?aiea eiee?anoaa i?enoo-
– o?iiaioeoiiaiey (iaiaa 100000 iee);
iia noaiiea?aee) auee caoeene?iaaiu e eiioo ea?aiey
– iia?aoee ia aieiaiii iicaa e iicaiii?ieea;
o 3 iaoeaioia. Ie a iaiii neo?aa ia auei e?iaioa?aiee
– ca?aaeno?e?iaaiiay aeia??oanoaeoaeuiinou e aa-
e noaoenoe?anee ainoiaa?iuo eciaiaiee ni noi?iiu ii-
ia?eio;
eacaoaeae naa?ouaa?uae nenoaiu e?iae: ai ea?aiey
– caaieaaaiey, nii?iai?aa?ueany ia?ooaieai
A?OA nae – 30,8±1,1, iinea ea?aiey A?OA – 31,2±2,3;
i?ioannia naa?ouaaiey e?iae.
IE% ai – 87,2±4,5, iinea – 85,3±4,5; OA nae ai –
I?ioeeaeoeea aaiiciuo o?iiaicia e OYEA n iiii-
10,1±2,1, iinea – 9,8±1,5; OA a/e ai – 3,4±0,4, iinea –
uu? IIA iniiaaia ia ii?aaaeaiee noaiaie ?enea eo
3,1±0,3; O? ai – 170 000±69,1, iinea 16 600±58,6 (?>0,05).
aicieeiiaaiey aey ea?aiai iaoeaioa eiaeaeaoaeuii e
Oaeei ia?acii, aieuoeinoai iaoeaioia n inei?-
ioianaiee aai e iaiie ec o?ao eaoaai?ee ?enea: ieceee,
iaiiuie oa?aiaaoe?aneeie caaieaaaieyie i?e iaee?ee

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