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I
Ei




Oinoiieoei yaeyaony i?aia?aoii aoi?iai auai?a. E iaainoaoeai ii?ii

?en. 1. ?oanoaeoaeuiinou iaeaieaa ?anoi ano?a?a?ueony
ioianoe aunieee i?ioaio ?acaeoey aea?ae iinea i?eaia i?aia?aoa.
aicaoaeoaeae eioaeoee ii?aauo iooae
Iaooi?e?iaaiiua oeiieiiu – iaeeaeeniaay, ieiaieaeaaay eeneioa, ieni-


Oaaeeoa 2. Iniiaiua oa?aeoa?enoeee aeieiae?aneiai aaenoaey i?aia?aoia eeanna
ooi?oeiieiiia

Oe?ieee aioeiee?iaiue niaeo? aaenoaey: a?aiiiei?eoaeuiua Ia?aie?aiiue niaeo? aaenoaey, i?aeiouanoaaiiay
e a?aiio?eoaoaeuiua ay?iaiua e aiay?iaiua aaeoa?ee, aeoeaiinou a ioiioaiee Enterobacteriaceae
ieeiaaeoa?ee, ieeiieaciu, oeaieaee, ?eeeaonee, ai??aeee
Au?a?aiiue iinoaioeaeioe?aneee yooaeo Iinoaioeaeioe?aneee yooaeo neaai au?a?ai eee ionoonoaoao
Aunieay aeiainooiiinou Aeiainooiiinou iaaunieay
Iioeiaeuiua oa?iaeieeiaoe?aneea naienoaa, Ieceea eiioaio?aoee a nuai?ioea e?iae,
oi?ioaa i?iieeiiaaiea a i?aaiu, oeaie, aeieiae?aneea ieioia i?iieeiiaaiea a i?aaiu, oeaie, eeaoee;
?eaeinoe (aey iaeioi?uo i?aia?aoia – ?a?ac AYA) e a eeaoee aunieea eiioaio?aoee a ii?a
Oe?ieea iieacaiey e i?eiaiaie?: aaeoa?eaeuiua eioaeoee Ia?aie?aiiua iieacaiey e i?eiaiaie?: aeaaiui ia?acii
?acee?iie eieaeecaoee, oeaieaeicu, ieeiaaeoa?eicu eioaeoee ii?aauaiayueo iooae, iaeioi?ua eeoa?iua
(aey iaeioi?uo i?aia?aoia a eiiieaeniie oa?aiee), eioaeoee (aecaioa?ey, yioa?ieieeou); ionoonoaea nenoaiiiai
?eeeaoneicu, ai??aeeic. Nenoaiiia aaenoaea aaenoaey i?e aaia?aeeciaaiiuo eioaeoeyo
i?e aaia?aeeciaaiiuo oi?iao eioaeoee.
I?eiaiaiea aioo?u, ia?aioa?aeuii I?eiaiaiea oieuei aioo?u
Ioiineoaeuii ieceay oiene?iinou Ioiineoaeuii ieceay oiene?iinou
A?o?ioiene?iinou a yenia?eiaioa aey iaiieiaic?aeuo A?o?ioiene?iinou a yenia?eiaioa aey iaiieiaic?aeuo
?eaioiuo a ii?aaaeaiiua aic?anoiua ia?eiau ?eaioiuo a ii?aaaeaiiua aic?anoiua ia?eiau
Oi?ioay ia?aiineiinou aieuiuie Oi?ioay ia?aiineiinou aieuiuie
I?eiaiaiea o ac?ineuo aieuiuo; ia?aie?aiey e i?eiaiaie? I?eiaiaiea o ac?ineuo e a iaaeao?ee
a iaaeao?ee ia iniiaaiee yenia?eiaioaeuiuo aaiiuo (ianiio?y ia aaiiua ii a?o?ioiene?iinoe a yenia?eiaioa)


480 13, 7, 2005
oOaeCOa a aOaAeeiCe
I.,–a.,1999.–e.5–9 tions. J Chemother 1997 Jun;9(3):203–7.
5. Mathew E., Gorbach SL. Practice guidelines: urinary tract infections . IDCP.–1995.– 4:241–54. 27. Menday AP. Symptomatic vaginal candidiasis after pivmecillinam and norfloxacin treatment of acute
6. Hooton T.M., Stamm W.E. // Infect. Dis.Clin. N.Am.–1997.–Vol.11.–P 551–581 uncomplicated lower urinary tract infection. Int J Antimicrob Agents 2002 Oct;20(4):297–300.
7. Foxman B.// Am J Public Health.– 1990.–Vol.80.–P.331 28. eA?AOIO‚ i.e. aIUAI?EE OO?AI E IO?A‚?‚O??E? OUUAE: OO‚?AIAII?A OO?O? I UA?OEE.
8. Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Dis Mon 2003 //i?IUAI. –2004.–3/4.–e.16–22
Feb;49(2):71–82 29. Shrestha N.K., Tomford J.W. Fosfomycin: A Rewiew. Infectious // Diseases in Clinical Practice.–
9. eU??UIOIEE a.e., eUI?OIEE C.C., eA?EI e.C., A·??O‚ u.e e?IUE?AOIEA OO?O? I ‚?·O?U 2001.– Vol. 10.– P. 255–260.
IUE·EOUEIO‚ O?E IAOOIOEIAII?? EIUAI?E?? IO?A‚?‚O??E? OUUAE // i?OIO„E?.– 30. Perri M.B., Hershberger E., Ionescu M., Lauter C., Zervos M.J. In vitro susceptibility of van-
2002.–2.–e.8–14 comycin–resistant enterococci (VRE) to fosfomycin // Diagn Microbiol Infect Dis.– 2002.– Vol. 42.–
10. Baily R.R //Int.J.Antimicrob.Agents.–1992.–Vol.2.–P.19–21 N.4.– P. 269–71.
11. Durier J.L. Anti–anaerobic antibiotic use in chronic inflammation, urgency, frequency, urge–incon- 31. AI?A‚ u.E., CEI?O‚ A.a., COOIO·OEIEIO‚ C.A. eOU??E ?EOUEU: ?UEOIO„E?, IIEIEI, IA?AIEA //
tinence and in interstitial cystitis //Interstitial Cystitis symposium, National Institutes of Health, aA??EE ‚??.– 2002. – 4.
Bethesda,–1995.–P.112 32. Stein GE. Fosfomycin tromethamine: single–dose treatment of acute cystitis. Int J Fertil Womens
12. Naber K.G.//Curr.Opin. Urol.–1999.–Vol.–9.P.57–64 Med 1999 Mar–Apr;44(2):104–9.
13. Warren JW. Practice guidelines for the treatment of uncomplicated cystitis. Curr Urol Rep 2001 33. aO?I e.A., eU??UIOIEE a.e., eUI?OIEE C.C., a.A.eEI?IO‚, aOOO‚ a.C., oA‚AIA‚ A.c. aEI-
Aug;2(4):326–9 ?O·EOIO„E?AOI? ??IUA?EOUEI E IIEIE?AOI? ?UUAIUE‚IOOU? UOOUOIE?EI.// i?OIO-
14. Uncomplicated UTIS in adults. //E.A.U.Guidlines on urinary tract and male genital tract infec- „E?.–2004.–3.–e.18–21.
tions.–P.9–14.
15. Bishop M.C. Uncomplicated urinaru tract infection.//EAU Updated Series.– Sept.–2004.–Vol.2–Issue
3.–P.143–150.
16. Nicolle L. Empirical treatment of acute cystitis in women.// Int J Antimicrob Agents 2003
Jul;22(1):1–6.
17. aOOUIEI c.A, a.e. eU??UIOIEE, e.A.aO?I, e.C.eAU?O‚. aAUOE?AOIEA ?AIOIAI?EE OO IA?A-
IE? EIUAI?EE IO?A‚?‚O??E? OUUAE. a. 1999.
18. eAEOI? O.c., uIO‚IA‚ C.e. AIUEIEI?O·I?A O?AO?U? „?UOO? UUO??EIOIOIO? ‚ IIEIE?A-
OIOE O?IUEIA. a.:aeEAiA, 1998:13.
19. uIO‚IA‚ C.e., uIO‚IA‚ e.C. e?EOII?I? IUEIEI?O·I? UA?OE?. a.:aEUA?, 2003:270–275
20. Pummer K., Flesoxin versus Norfloxacin in the Treatment of Urinary Tract Infections: A Multicenter,
Double–Blind, Prospective, Randomised, Comparative Study. Am J Med 1993; 94 (Suppl.3A):108–113.
21. Auquer F. Cordon F. Gorina E. Caballero JC. Adalid C. Batlle. Single–dose ciprofloxacin versus 3 days
of norfloxacin in uncomplicated urinary tract infections in women. Clin Microbiol Infect 2002
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UEII ‚OA·UEUAIAE EIUAI?EE IO?A‚?‚O??E? OUUAE U I·UIUO?I?? O?EAIUO‚. KRKA. Novo
mesto, 1998:1–16
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OEIOOAEUI. a., 1999, 23–29.
24. Pimentel FL. Dolgner A. Guimaraes J. Quintas M. Mario–Reis J. Efficacy and safety of norfloxacin
800 mg once–daily versus norfloxacin 400 mg twice–daily in the treatment of uncomplicated urinary
tract infections in women: a double–blind, randomized clinical trial. J Chemother 1998 Apr;10(2):122–7.
25. Wensing JW. Vlasveld LT. Immune thrombocytopenia attributed to norfloxacin. Ned Tijdschr
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prim–sulfamethoxazole and nitrofurantoin on fecal flora of women with recurrent urinary tract infec-


Oaaeeoa 3. Niaeo? aaenoaey iniiaiuo o?iaioenaioeeia
(–) (+) –

St. aureus Streptococcus



?– (+)
?– (–)
Ps. aerugenosa




Mycoplasma
Enterobacter




Pr. mirabilis


Pr. vulgaris




Chlamydia
Klebsiella




pyogenes


faecalis
E. coli




Spp.




Spp.




Noeuoaieeaieau ++ + + + + ± +
O?eiaoii?ei/
noeuoaiaoienacie ++ + + + + ± + + + + +
Iaeeaeeniaay eeneioa ++ + ±
Ieieieaeaaay eeneioa ++ ++ ++ +
I?iecaiaiua
ieo?ioo?aia ++ + + + ± + + ± ± +
I?iecaiaiua
8–ieneoeiieeia ++ + + + ± + + + + +
Ii?oeienaoei ++ ++ ++ ++ ++ + ± + + ± ± ±
Oei?ioeienaoei ++ ++ ++ ++ ++ ++ ± ++ ++ ± ± ± + +
Ioeienaoei ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++
± – iaiinoiyiinoai i?eciaea, oia?aiiay ?oanoaeoaeuiinou
+ – ?oanoaeoaeai
++ – aunieay ?oanoaeoaeuiinou


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