. 1
( 2 .)



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eOCaAieaeEau

aA?AIEA OOUAO?U?OA: ‚IE?IEA I ????A‚U? UII?
?AIE?I?? O?OUE‚O‚OOOIEUAI?I?? O?AO?UO‚
c.C. oE?OO‚
e?OUAOOO?
aaA EIAIE a.a. eA?AIO‚
eacaieai aey eniieuciaaiey IIAI yaeyaony iaee?ea
eiiaeaeuiua nonoaau (aea?o?iciua) iaania?eaa?o
N aoi?e?iiai neiiaeoa. Ii nia?aiaiiui i?aanoaaeaieyi
aae?aiea ?acee?iuo ?anoae ooeiaeua ?aeiaaea.
Einou a neiiaeaeuiii nonoaaa iie?uoa aeaeeiiaui o?y- neiiaeo iaeeaaoii ?acaeaaaony i?e IA, iiyoiio ca ?oaa-
uii – aunieiyeanoe?iie oeaiu?, niya?a?uae aaaeaiea ?ii i?eiyo oa?iei «inoaia?o?eo», iia?a?eeaa?uee ii-
ia oaa?ao? einoio? oeaiu. A o?yuaaie oeaie ionoonoao- noiyiiinou ainiaeeoaeuiiai eiiiiiaioa a neiiaee. Aaco-
?o e?iaaiiniua ninoau, e ieoaiea aai inouanoaeyaony neiaii, IIAI aieaa yooaeoeaii eoie?o?o aieu i?e IA,
ca n?ao neiiaeaeuiie ?eaeinoe. Oaeei ia?acii, yea- iaiaei iaecaa?iinou ?acaeoey iiai?iuo yooaeoia ni noi-
noe?iinou o?yua aa?ia ia oieuei aey inouanoaeaiey ?iiu ?EO, ia?aie, ii?ae e a?. i?e iiaaaeaiee neioaca oe-
aii?oecaoeiiiuo ooieoee, ii e aey nianoaaiiiai iaan- ceieiae?anee cia?eiuo i?inoaaeaiaeiia (OIA–1 iiin?a-
ia?aiey ieoaoaeuiuie yeaiaioaie, «aieouaaaiuie» ec aiaaiiue iaoaieci) eeieoe?oao iacia?aiea ianaeaeoea-
neiiaeaeuiie ?eaeinoe i?e naaaeaiee o?yua. iuo a ioiioaiee OIA IIAI. Oai aieaa ?oi aieuoeinoai
I?e ?acaeoee aaaaia?aoeaiuo i?ioannia a o?yua- aieuiuo IA – yoi ii?eeie eiioeiaaio, ?oi yaeyaony oaeoi-
aie oeaie aoi?e?ii no?aaa?o e ana inoaeuiua no?oeoo?u ?ii ?enea ?acaeoey iiai?iuo yooaeoia ianaeaeoeaiuo
nonoaaa: a neiiaeaeuiie iaiei?ea ?acaeaaaony ainiaea- n?aanoa. Eiaiii o yoie eaoaai?ee aieuiuo e noaee oe?iei
iea (neiiaeo), a iiaea?auae einoe oaaee?eaa?ony aano- i?eiaiyouny naeaeoeaiua (iaeieneeai, ieianoeea) e nia-
?oeoeaiua i?ioannu (noaoiia?aeuiua eenou) e ia?ae- oeoe?aneea eiaeaeoi?u OIA–2 (Oaeaa?aen), ?oi iicaiee-
eaeuii n ieie eiiiainaoeiiiia ?ac?anoaiea einoiie ei cia?eoaeuii oiaiuoeou ?enei inei?iaiee a ia?ao?
oeaie (inoaioeou), ineaaaaaao nooi?eeuii–nayci?iue i?a?aau ni noi?iiu neecenoie ?aeoaea e eeoa?ieea [2,3,4].
aiia?ao, ?oi i?eaiaeo e ianoaaeeuiinoe nonoaaa. Iaiaei nouanoao?o e a?oaea aniaeou, eeieoe?o?uea
Aaaaia?aoey o?yua yaeyaony oaio?aeuiui caa- iacia?aiea ianaeaeoeaiuo IIAI i?e IA. ?ya aaoi?ia
iii iaoiaaiaca naiiai ?ani?ino?aiaiiiai ?aaiaoiei- ?acaaeyao IIAI ia iioaioeaeuii «oiia?i–aa?anneaiua»
ae?aneiai caaieaaaiey – inoaia?o?ica (IA). e «oiia?i–i?ioaeoeaiua» [5]. Aey iiieiaiey aicii?iie
Iaiei ec iniiaiuo eeeie?aneeo i?iyaeaiee inoaia?o- iiei?eoaeuiie eee io?eoaoaeuiie ?iee IIAI a ?acaeoee
?ica (IA) yaeyaony aieu, iiyoiio a ia?ao? i?a?aau aieu- e oa?aiee IA neaaoao ia?aoeou aieiaiea ia iaeioi?ua
iui iacia?aaony aiaeuaaoe?aneay oa?aiey. ?aeiiaiaaoee aniaeou iaoiaaiaca yoiai caaieaaaiey. Ia ?enoiea 1 noa-
AIC ii ea?aie? IA aeiaie?anee eciaiyeenu n 1995 a. ii iaoe?anee i?aanoaaeaiu i?ioannu, i?eaiayuea e i?i-
2003 a., io?a?ay iieo?aiea iiauo aaiiuo ia yooaeoeaii- a?anne?o?uae aaa?aaaoee iao?eena o?yua. Aeaii, ?oi
noe eee iaainoaoi?iie yooaeoeaiinoe ?acee?iuo ea?aa- iniiaiuie i?ioannaie, i?eaiayueie e ?acaeoe? IA,
iuo ia?ii?eyoee (oaae. 1). Ia nia?aiaiiii yoaia n?eoaao- yaey?ony aano?oeoey o?yua, ?eaeaiinou noaoiia?aeuiie
ny, ?oi iaacaieeaaiea i?e IA iaai ia?eiaou n iacia?aiey einoe e neiiaeaeuiia ainiaeaiea.
aoaoaieiioaia (ia?aoaoaiiea), i?iaaaaiey i?oiiaae?a- N?eoaaony, ?oi iiaaaeaiea ia?aciaaiey i?iainiaee-
neeo ia?ii?eyoee, e iacia?aiey ianoa?ieaiuo i?ioeai- oaeuiuo i?inoaaeaiaeiia, oeoieeiia, naiaiaiuo eenei-
ainiaeeoaeuiuo i?aia?aoia (IIAI) ec a?oiiu OIA–2 na- ?iaiuo ?aaeeaeia, i?ioaac (oi anou iiaaaeaiea neiiaeoa)
eaeoeaiuo eiaeaeoi?ia. Aaeaa iacia?a?ony «oiia?ii?ioa- ii?ao eiaou e iaeioi?ia «oiia?ii?ioaeoeaiia» aaenoaea
eoeaiua» i?aia?aou, e oieuei i?e iaiaoiaeiinoe iacia?a- [5,6]. Iicaiaa iiyaeeenu iiaua aaiiua, eioi?ua inaaua-
?o ianaeaeoeaiua IIAI. N?eoaaony, ?oi aoaoaieiioai ?o aeeyiea ianaeaeoeaiuo IIAI ia neioac iao?eena o?y-
eiaao eo?oo? ia?aiineiinou, ?ai ianaeaeoeaiua IIAI. ua. Iaeioi?ua IIAI (eaoi?ioai, naeeoeeaou, oaiii?i-
Iaiaei iaaaaiaa enneaaiaaiea [1] iieacaei, ?oi eniieuci- oai) i?e nenoaiaoe?aneii i?eiaiaiee a oa?aiea 4–6 ian.
aaiea ia?aoaoaiiea a aunieeo oa?aiaaoe?aneeo aicao onei?y?o aano?oeoe? o?yua, oaiaoay neioac i?inoaaeai-
eiaao iaeiaeiao? ia?aiineiinou n IIAI. Iniiaiui ii- aeiia, i?ieeoa?aoe? oiia?ioeoia, eiaeae?oy oa?iaiou,
Oaaeeoa 1. ?aeiiaiaaoee AIC ii oa?iaeioa?aiee IA eieaiiiai e oaciaaa?aiiiai nonoaaa
1995 2000 2003
1. A/n aaaaaiea AE 1. Ia iieieaiua aiaeuaaoeee 1. Ia iieieaiua aiaeuaaoeee
(oieuei a eieaiiue nonoaa) (aoaoaieiioai) (aoaoaieiioai)
2. Ia iieieaiua aiaeuaaoeee
2. OIA–2 naeaeoeaiua IIAI 2. I?oiiaae?aneea ia?ii?eyoey
(aoaoaieiioai)
3. Eieaeuiua aiaeuaaoeee 3. Ianaeaeoeaiua IIAI + iecii?inoie eee
3. OIA–2 naeaeoeaiua IIAI
(iace, e?aiu, aaee) eiaeaeoi?u i?ioiiiie iiiiu (i?e ?enea aano?iiaoee)
4. «Oiia?ii?ioaeoi?u» – oiia?ieoei
4. IIAI 4. A?oaea aiaeuaaoeee (o?aiaaie, eiaaei)
noeuoao, niee ae?eicaieia e a?.
5. Iieieaiua aiaeuaaoeee
5. A/n AE (oieuei a eieaiiue nonoaa) 5. A/n aeaeo?iiai
(eiaaei, o?aiaaie)
6. A/n aeaeo?iiai 6. Aaieaai/niy
7. Eieaeuiua aiaeuaaoeee (iace, e?aiu, aaee) 7. Ianaeaeoeaiua IIAI
8. Oe?o?ae?aneia ea?aiea


539

13, 8, 2005
eOCaAieaeEau
iaiaoiaeiua aey neioaca aeeeicaieiiaeeeaiia (AAA) oaeoeaiinou a/n aaaaaiee AE caaeneo io iaee?ey neii-
[7,8,9]. O?eouaay, ?oi AAA ea?a?o oaio?aeuio? ?ieu a noi- aeoa, auai?a i?aia?aoa e oeia ii?a?aiiiai nonoaaa.
Iniiaiui iieacaieai aey a/n aaaaaiey AE yaey-
?aiieaeoey?iie i?aaiecaoee aa?aaaoia i?inoaaeaiaeiia
aony iaee?ea ainiaeaiey a nonoaaa – neiiaeoa. E ni-
e, aneaanoaea yoiai, a aeiiaoaie?aneie ooieoee o?yua,
i?eiaiaiea ianaeaeoeaiuo IIAI i?eaiaeo e au?a?aiii- ?aeaie?, ia?aaei AE a/n iacia?a?ony i?e iaee?ee oieu-
io nie?aie? niaa??aiey aeaeo?iiaia a o?yua i?e yenia- ei aieaaiai neia?iia. Iaiiiiei, ?oi aieu i?e IA ia
?eiaioaeuiii IA [10] e a o?yua ?aeiaaea [11,12], ia caae- anaaaa iaoneiaeaia iaee?eai neiiaeoa. Iiyaeaiea aiee
nyuaa io aic?anoa iaoeaioia [13,14]. Ioaiea aeeyiey ia i?e IA ii?ao auou neaanoaeai ?acee?iuo i?e?ei [25]:
o?yu iaeioi?uo ianaeaeoeaiuo IIAI iieacaea caaeny- 1. neiiaeo
uea io aicu ?acee?ey aicaaenoaey ia eaoaaiee?aneea e 2. o?aaaeoey?iua iee?iia?aeiiu
aiaaiee?aneea i?ioannu. Aaaaaiea ieceeo aic IIAI 3. aioo?eiaaoeey?iay aeia?oaicey
(5 ia/ea oeai?ioaiiaie eeneiou) a yenia?eiaioa in vitro 4. aaaeaiea ia iaia?aiio? noaoiia?aeuio? einou
i?eaiaeei e nie?aie? aaa?aaaoee i?ioaiaeeeaiiauo aa- 5. niaci ieieinonoaaiuo iuoo
?aaaoia e iiauoaie? neioaoe?aneie aeoeaiinoe oiia?i- 6. aaaaia?aoeaiua eciaiaiey eio?aa?oeeoey?iuo
oeoia, a aaaaaiea aieaa aunieeo (oa?aiaaoe?aneeo) aic naycie
aucuaaei onei?aiea eaoaaiee?aneeo i?ioannia e iioa?? 7. iaee?ea inoaioeoia
i?ioaiaeeeaiia ec o?yuaaie oeaie [15]. Aiaeiae?iua aai- Eeeie?anee i?e ?acaeoee neiiaeoa, iiieii aiee,
iua auee iieo?aiu aey aeeeioaiaea e eiaiiaoaoeia. eiaao ianoi oo?aiiyy neiaaiiinou (ai 30’ i?e a?o?ica
E?iia oiai, auei iieacaii, ?oi i?e aeeoaeuiii ea?aiee aieuoeinoaa iaeeeo e e?oiiuo nonoaaia e ai 60’ i?e ia-
aeeeioaiaeii e oeai?ioaiiaie eeneioie i?ienoiaeo ae- ee?ee eiena?o?ica), oia?aiiay i?eiooeinou ie?o?a?ueo
aaeu inoaioeoia a noaoiia?aeuiie einoe [16]. nonoaa oeaiae. Iaee?ea neiiaeoa ii?ao auou iiaoaa?-
Neioac AAA oiia?ioeoaie i?e ?acaeoee IA nie?aao- ?aaii i?e oeuo?acaoeiaii enneaaiaaiee. ?aeiiaiaaoee
ny [17]. A oaaeeoa 2 io?a?aia neioaoe?aneay aeoeaiinou Ieienoa?noaa ca?aaiio?aiaiey ?O ii aioo?enonoaaiui
eeaoie aieiaee e eiiaeeonia aaa?aiiie einoe i?e ionoo- iaieioeyoeyi (2001 a.) [26] ii?aaaey?o ionoonoaea ain-
noaee IA e i?e ?acee?iie oy?anoe IA. Enneaaiaaiea in iaeaiey («nooie» nonoaa) eae i?ioeaiiieacaiea aey aaa-
vitro i?iaaaaiiia o 300 aieuiuo ii enneaaiaaie? aeey- aaiey AE. Eia?ony aaiiua i oii, ?oi iaee?ea auiioa e
iey IIAI ia neioac AAA o?yuii aieiaee aaa?a [17] ii- aai au?a?aiiinou annioee?o?ony n yooaeoeaiinou? AE
eacaei, ?oi a iaeaieuoae noaiaie io?eoaoaeuiui aeey- [27]. I?iaie?eoaeuiinou yooaeoa a/n aaaaaiey AE i?e
ieai ii n?aaiaie? n eiio?ieuiie a?oiiie ia ea?aiiuo IA ia aaeeea e aa?ue?oao io 1 ai 3–4 iaaaeu [24].
aieuiuo iaeaaaee eaoi?ioai, eiaiiaoaoei e iai?ienai
!
e iaiuoei – aeeeioaiae, ie?ieneeai. Ia ?enoiea 2 i?i-

aaiiino?e?iaaii n?aaieoaeuiay ?anoioa oaaee?aiee e
« » – /
nie?aiey neioaca AAA o aieuiuo, ea?aiiuo ?acee?iuie
IIAI. Ia ?enoiea 3 iieacaii ia?anoaiea ?anoiou ?aio-
aaiieiae?aneiai i?ia?anne?iaaiey (aaa?aaaoee o?yua) Iaoaieciu, ii?aaaey?uea yooaeoeaiinou AE i?e IA
i?e i?eiaiaiee eiaiiaoaoeia, iai?ienaia e ia?aoaoa- ai eiioa ia yniu. Ii yenia?eiaioaeuiui aaiiui au?a?ai-
iiea ii n?aaiaie? n ieaoaai [18,19]. iinou ainiaeaiey ei??aee?oao ni nei?inou? iioa?e o?yua-
A enneaaiaaieyo in vitro e in vivo auei iieacaii, ?oi ia- aie oeaie, eeeie?aneea enneaaiaaiey oae?a iiaoaa??aa?o,
?oi iaee?ea ainiaeaiey a eieaiiii nonoaaa annioee?o-
naeaeoeaiua e oia?aiii naeaeoeaiua IIAI eiaeae?o?o
aony n aieaa iaaeaaii?eyoiui enoiaii e ?aioaaiieiae-
neioac i?inoaaeaiaeiia o?yua [20,21], io?eoaoaeuii aeeyy
?aneei i?ia?anne?iaaieai IA. N yoie oi?ee c?aiey iiaa-
ia iaoaaieeci i?ioaiaeeeaiia e aeaeo?iiaia. A iaaaaiai
enneaaiaaiee in vitro a o?yua, iieo?aiiii i?e iia?aoea- aeaiea ainiaeaiey a neiiaeaeuiie iaia?aia eiaao «oiia-
iii ea?aiee aieuiuo IA, auei eco?aii aeeyiey Oaeaa?a- ?ii?ioaeoeaiia» aaenoaea. Iaiaei a ?yaa a?oaeo enneaai-
ena e aeeeioaiaea ia i?ioannu iaoaaieecia o?yua [22]. aaiee auei iieacaii, ?oi AE ia anaaaa ieacuaa?o iiei?e-
Oaeaa?aen a ioee?ea io aeeeioaiaea: 1) oaaee?eaae ?enei oaeuiue yooaeo e a iaeioi?uo neo?ayo eo aaaaaiea ii?ao
3
[ H]–PG iieaeoe, o?anoao?ueo a neioaca i?inoaaeaiaeiia i?eaiaeou e iioa?a i?ioaiaeeeaia o?yua [28].
o?yua (?en. 4); 2) oaaee?eaae ?enei aiiau neioace?iaaiiuo N o?aoii oa?iaeiaeiaieee nia?aiaiiuo AE, en-
iieaeoe aeaeo?iiiaie eeneiou; 3) caiaaeye ?ac?ooaiea iieucoaiuo aey a/n aaaaaiey, iiaoi?iia eniieuciaaiea
3
naoe [ H]–HA iieaeoe, o?anoao?ueo a neioaca aeaeo?iii- yoiai iaoiaa a ea?aiee IA aicii?ii oieuei ?a?ac 4–6
aie eeneiou. Yoi iiei?eoaeuiia aeeyiea Oaeaa?aena ia iaaaeu. I?e i?aaeeuii a?ai?e?iaaiiie oa?aiee yoio
iaoaaieeci aeaeo?iiaia ii?ao eiaou aieuoia aeieiae- Oaaeeoa 2. Neioaoe?aneay aeoeaiinou eeaoie
?aneia e eeeie?aneia cia?aiea. N?eoaaony, ?oi ea?aaiia i?e ?acee?iie oy?anoe IA e o cai?iauo
e?aae
aaenoaea Oaeaa?aena ia o?yu naycaii n i?aaioa?auaieai
eiaeaeoee neioaca i?inoaaeaiaeiia o?yua, eiaooe?oaiia
eioaeaeeeiii 1 e oaeoi?ii iae?ica iiooiee ?–[23].
(±?) (±?)
Aioo?enonoaaiua (a/n) eiuaeoee ae?eiei?oeeieaia
Aac IA 185 3,63±0,30 15 6,02±0,41
(AE) oe?iei eniieuco?ony a ea?aiee IA. Iaiaei ?a-
IA eaaeee 101 2,45±0,15 12 3,76±0,16
coeuoaou oaeiai ea?aiey iiaoo auou ?acee?iuie, ?oi
IA oia?aiiue 74 2,01±0,14 15 2,39±0,14
iaoneiaeaii iaiaeiaeiaie ?ieu? ainiaeeoaeuiiai
IA oy?aeue 66 1,31±0,14 5 1,95±0,1
eiiiiiaioa a ?acaeoee e i?ia?anne?iaaiee IA o ?ac-
Aanu IA 486 1,88±0,38 60 3,73±0,36
ee?iuo aieuiuo e a ?acee?iua oacu aieacie [24]. Yo-

540 13, 8, 2005
n?ie ainoaoi?ai aey ?aaeecaoee yooaeoa aaceniuo (iaaeaiiiaaenoao?ueo) i?ioeaia?o?iciuo i?aia?aoia e iaia-
oiaeiinou a iiaoi?iuo aaaaaieyo AE ioiaaaao. Neaaoao o?eouaaou, ?oi anee iaiie?aoiia aaaaaiea AE i?eaaei
eeou e e?aoeia?aiaiiiio yooaeoo (1–2 iaaaee), iiaoi?iua aaaaaiey ai?iiiaeuiuo n?aanoa o?aao?o iniauo iiea-
caiee. Yoi naycaii n oai, ?oi i?e?eiie oneeaiey aieae ii?ao auou ia iaino?aiea neiiaeoa, a iia?a?aaiea o?yua,
eioi?ia ii?ao i?ia?anne?iaaou i?e iiaoi?iuo aaaaaieyo AE. Oaeei ia?acii, ionoonoaea yooaeoa i?e iaiie?aoiii
aaaaaiee AE yaeyaony i?ioeaiiieacaieai aey aaeuiaeoeo a/n eiuaeoee i?aia?aoa.
Iaiaoiaeii iiiieou, ?oi i?aauoaiea aicu AE, a oii ?enea e i?e a/n aaaaaiee, aaaao e oaaee?aie? ?anoiou ii-
ai?iuo yooaeoia, eae naieo noa?ieaiuo ai?iiiia, oae e ia?aeaoaeuiuo yaeaiee, naycaiiuo n a/n iaieioeyoeae.
I?aeoe?anee o anao aieuiuo iaae?aaaony ananuaaiea AE ec iieinoe nonoaaa a nenoaiiue e?iaioie, eieaeuiay oa-
?aiey AE, eae e nenoaiiay, i?eaiaeo e oaiaoaie? ine aeiioaeaioc–aeiioec–iaaii?a?ieee [29], au?a?aiiinou ei-
oi?iai i?iii?oeiiaeuia ?eneo nonoaaia, a eioi?ua aaiaeeenu AE. Cia?eoaeuiua iiai?iua yooaeou AE i?e i?aau-
oaiee eo aicu ii?aaaey?ony iniaaiiinoyie oa?iaeiaeiaieee yoeo i?aia?aoia. AE – yoi eeiioeeuiua aauanoaa,
eioi?ua naycuaa?ony ni noa?ieainaycuaa?ueie aaeeaie
– aeuaoieiii e o?ainei?oeiii. Aunieea aicu AE oiaiu-
Iaoaie?aneea oaeoi?u oa?o eo niiniaiinou naycuaaouny n aaeeii n 80–90% ai
60–70% ca n?ao ianuuaiey o?ainei?oeinaycuaa?ueo
o?anoeia. A nayce n yoei aieuoia eiee?anoai i?aia?aoa
Iiaeoeeaoey
Aeoeaaoey niiniaii aeoooiae?iaaou a ia?eoa?e?aneea oeaie, ?oi
oea?eeey?iie
oiia?ioeoia
nii?iai?aaaony oaaee?aieai iiai?iuo ?aaeoee AE [30].
no?oeoo?u oea?eee
Iaeaieaa ?anouie iiai?iuie yooaeoaie AE i?e a/n
aaaaaiee yaey?ony:
Oaaee?aiea
iaoaeeii?ioaac – ioaaoiue 1. eioaeoeiiiua inei?iaiey, ?anoioa eioi?uo aic-
Iaaooaiea
neioac IA
?anoaao i?e au?a?aiiie aaoi?iaoee nonoaaia e au?a-
e eieeaaaia o?yua
– I?ioaeiu
?aiiie aano?oeoee o?yua e iiaea?auae einoe;
?aiia oaaee?aiea – AIE
i?ioaieeoe?aneie – IAA2
2. iaino?aiea neiiaeoa ii oeio e?enoaeee?aneie a?o-
aeoeaiinoe – Naiaiaiua
?aaeeaeu ?iiaoee;
Nie?aiea
3. ia?anoaiea aano?oeoee o?yua e einoe, aieiou ai
o?iaiy IA
anaioe?aneeo iae?icia (iniaaiii i?e ?anouo iiaoi?iuo
Oaaee?aiea IA
aaaaaieyo) – noa?ieaiay a?o?iiaoey.
e aaa?aaaoee
eieaaaia
?a?a ano?a?a?ony:
4. ?ac?uau nooi?eeee, iia?a?aaiea ia?aiuo noaieia
(iniaaiii ?anoi iia?a?aaiea n?aaeiiiai ia?aa a ea?-
?eaeaiinou
noaoiia?aeuiie
Aano?oeoey o?yua
iaeuiii eaiaea);
einoe
5. iaoi?iia e?iaioa?aiea;
Oaaee?aiea
6. iaie?aaoeo;
aea?aaee?aneie
O?aaiaiou iaa?ocee
7. caaiyy iiaeainoey?iay eaoa?aeoa;
a neiiaeaeuiie
Eciaiaiea
?eaeinoe
8. ?aaeoee aeia??oanoaeoaeuiinoe [31].
eoa?eeaoee
Oiaiuoaiea ?acaeoea «noa?ieaiie a?o?iiaoee» (ii oeio nonoaaa
ieioiinoe e
Oa?ei), eae iieaaa?o, naycaii n eaoaaiee?aneei aaenoae-
yeanoe?iinoe
Neiiaeaeuiia
inoaioeou Noaaeeecaoey
ainiaeaiea ai AE [32] eee n aiaeuaaoe?aneei yooaeoii a/n eiuaeoee
enoii?aiey
AE, ?oi iicaieyao aieuiui oaaee?eaaou iaa?oceo ia nonoa-
eieeaaaiiiauo
oea?eee
au e oai naiui niinianoaiaaou i?ia?anne?iaaie? nonoaa-
Nae?aoey
iaaeaoi?ia iie aano?oeoee aieiou ai inoaiiae?ica [33]. Yoa iaoieiaey
?anoai?eiuo
ano?a?aaony ia ?anoi e, eae i?aaeei, naycaia n neeoeii ?a-
i?ioaac
IL–2
nouie (?aua 1 ?aca a ianyo) a/n eiuaeoeyie eee aaaaaie-
TNF
PGE2 ai i?aiu aieuoiai eiee?anoaa AE. Iniaaiii ia?aeaoaeuiu
Oaaee?aiea
aeoeaiinoe a/n aaaaaiey AE a oaciaaa?aiiua nonoaau, oai aieaa ii-
neiiaeaeuiuo
aoi?iua, iineieueo eiaiii a aieiaea aaa?aiiie einoe iae-
yiceiia
aieaa ?anoi ?acaeaaaony anaioe?aneee iae?ic, ?oi ?acei
?en. 1. Iaoioeceieiae?aneay aeaa?aiia inoaia?o?ica
oaaee?eaaao eiaaeeaecaoe? iaoeaioa.
Oaeei ia?acii, aioo?enonoaaiua aaaaaiey AE iiaoo
i?eiaiyouny oieuei i?e iaee?ee au?a?aiiiai aoi?e?iiai

neiiaeoa, i?e oi?ie?iaaiee eeno Aaeea?a, ii ia yaey?ony
niiniaii ai?iouny n aieu? i?e IA. ?aoaiea i iaiaoiae-
iinoe i?iaaaaiey yoeo iaieioeyoee neaaoao niaeaniau-
aaou n a?a?aie, i?iaiayueie aeniaina?iia iaae?aa-
iey e ea?aiea iaoeaioia n IA (?aaiaoieiaaie, oa?a-
iaaoaie), iaiaoiaeii o?eouaaou iaee?ea niioonoao?ueo
caaieaaaiee iaoeaioa e ioaieaaou aicii?iua inei?iaiey










. 1
( 2 .)



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