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anxiety disorders 267“8
synonyms 211
cerebral sarcoidosis 265
HASBAP methods 219“20
definition 263
ATPD, bipolar affective mixed states and
epilepsy 265
bipolar schizoaffective mixed states 220“1
general effect of comorbidity 270
ATPD compared with all groups 231
head injuries 265
ATPD compared with bipolar groups 227,
idiopathic dystonia 265
228, 229
learning disability 265
ATPD compared with mixed states 226, 226
medical conditions and neuropsychiatric
polymorphic ATPD, bipolar affective mixed
disorders 264“6
states and bipolar schizoaffective mixed
other psychiatric disorders 269
states 221, 222, 224
personality disorders 268“9
polymorphic ATPD compared with mixed
relevance 263“4
states 226, 227
stroke 265
nature of acute and transient conditions 217“19
substance-abuse disorders 266“7
gender differences 221
thyroid disorders 264
sufferer profile 218
tuberous sclerosis 265
polymorphic 36
definitions 382“3
predecessors 211
´´ design of clinical trials 379“82
bouffee delirante 215“16
difficulties in conducting trials 373“4
cycloid psychoses 212“15
epidemiology, phenomenology and comorbidity
other conditions 216“17
65“9
psychotic psychoses 216
alcohol and drug abuse 68, 69
children 66, 67
quetiapine 355
episode types 66
bipolar I and bipolar II disorders 100
family studies and genetics 28, 62“3
controlled studies for bipolar disorder 363“4
gender differences 62
elderly patients 260
lessons from clinical trials 375“9
rapid-cycling disorder 80
assessment challenges 378
daily mania and depression ratings 376
rapid-cycling disorder 61
longitudinal prognosis 29
age at onset 28
pathophysiology 63“5
biological aspects 311“12, 319
sleep“wake cycle 64
catecholamines 312“14
treatment 29, 369, 382
hormonal abberations 314“15
antidepressants 70
mood stabilizers 318
combination therapy 80“2
role of calcium 316“18
divalproex sodium 79
transmembrane ion fluxes 315“16
lamotrigine 71“7
biological data 28
lithium 77“9
characterization 24“8, 283
394 Index


onset 199, 200
rapid-cycling disorder (cont.)
schizoaffective psychosis 189
olanzapine 79
schizophrenia-like emotional psychoses 217
quetiapine 80
schizophreniform disorder 191
recommendations 69“70
Schneider, Kurt 189
venlafaxine 70
seasonal affective disorder (SAD) 283
ultrarapid cycling 332“3
secondary mania 257, 258
Raynaud™s disease 97
serotonin transporter 63, 290
reactive psychoses 216
sib-pair method 291
recurrent brief anxiety (RBA) 35, 110, 111
Soranus of Ephesos 6
recurrent brief depression see depression, recurrent
Staehelin, J. E. 217
brief (RBD)
Stransky, E. 163
recurrent brief hypomania (RBM) 35, 111, 114
strokes 69
Richarz, Frank 13, 159, 170
comorbidity with bipolar affective
risperidone 355
disorders 265
bipolar I and bipolar II disorders 100
subarachnoid hemorrhages 69
controlled studies for bipolar disorder 356“8
substance-abuse disorders, comorbidity with
elderly patients 260
bipolar affective disorders 266“7
mania 336
suicide risk
Rush, B. 160
bipolar disorders 92, 95
depression, recurrent brief (RBD) 122, 123“4
schizoaffective disorders 17, 187
mixed states 21
definition developments 188“92
lithium therapy 343
DSM-IV criteria 188
Systematic Treatment Enhancement Program for
ICD-10 criteria 188
Bipolar Disorder (STEP-BD) 379
schizoaffective mixed episode 187, 188, 192
characteristics 194“6
thyroid gland
types of episodes 196
abnormalities and disorders 68
disability pensions 200“2
comorbidity with bipolar affective disorders 264
duration 196“8, 197
role of lithium 78
frequency 198, 198“9
thyroid-stimulating hormone (TSH) secretion
gender differences 193, 199
rapid-cycling disorder 65, 68, 315
onset 199, 200
topiramate, use in bipolar I and bipolar II
schizoaffective mixed states 187“8, 202“3
disorders 100
see also mixed states
tranylcypromine 340
affective continuum 202
tricyclic antidepressants, use in bipolar I and bipolar
characterization 29“33
II disorders 100
concurrent and sequential types 31
tryptophan hydroxylase (TPH) 63
cross-sectional definition 30
polymorphisms 63
DSM-IV definition 29, 30
tuberous sclerosis, comorbidity with bipolar
ICD-10 definition 19
affective disorders 265
longitudinal definition 31
twin studies 278
current research
mood disorders 285, 285“6
Cologne Study 192“4
children and adolescents 288“9
HABILOS 194, 195
heritability 285, 286
study results
disability pensions 200“2, 201
unproductive mania 12, 13
episode characteristics 194“6, 196
episode duration 196“8, 197
valproate 317
episode frequency 198, 198“9
bipolar disorder in children and adolescents 245
gender distribution 199, 199
395 Index


mania, acute 334 atypical depression 138“9, 139“40, 145, 149
mixed states 23 atypical depression and menopause 140“1
vascular depression 257, 259 recurrent brief depression 117
venlafaxine, use in rapid-cycling disorders in suicide risk 122
women 70 mixed states 15, 53, 55
Vienna Research Criteria 45, 46 frequency 20
psychotic disorders, acute and transient 221
Wernicke, Karl 212 rapid-cycling disorder 27, 62
Weygandt, Wilhelm 9, 11, 11, 12, 163 venlafaxine 70
definition of mixed states 12“13 schizoaffective mixed episodes 193, 199, 199
first book on mixed states 10
Winnicott, Donald 326 ziprasidone 355
women controlled studies for bipolar disorder 364
bipolar II disorder 90 Zurich study 112
depression design 112

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