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human parturition 5, 37, 74, 77, 84
hypothalamic motor nucleus 208
intrauterine growth restriction 2, 45, 89,
neuroendocrine motor neurons 207, 208,
114 see also IUGR
209, 214
mammalian pregnancy 4
structural compartmentalism 208
protein-energy malnutrition 5
PVHmp afferents
preterm delivery
corticosterone 220, 226
CRH 11, 78, 79, 80
PVN 9, 10, 11, 93, 115, 131, 158, 162, 243,
glucocorticoids 121, 122, 133, 145, 146,
245, 246, 249, 250
167
pyschiatric disorders 156, 235, 254, 255,
IUGR 89
258
risk 78, 79, 84, 122, 166
tissue maturation 146
radioimmunoassay 42
preterm labor
real-time protein-coupled receptor 42, 43, 45
preterm birth 4
receptor mechanisms
CRH 11, 27, 90, 96, 98, 241
gamma amino butyric acid (GABA) 213
oxytocin 26
renin“angiotensin system (RAS) 151
peptide signaling 33
respiratory distress syndrome 7, 121
plasma concentration 78
reverse transcription polymerase chain
production of growth hormones (pGH)
reaction 54
101“103, 107
rodents 89, 99, 101, 104, 146
progesterone withdrawal 76, 84
role of PTHrP 44
programming HPA axis function
RT-PCR 42, 43, 45
adult disease 124, 125
animal evidence 124“126
secretogogue gene expression
body mass index 124
adrenalectomized (ADX) 206
glucose intolerance 124, 126
AVP mRNA 206
human and animal evidence 124
CRH mRNA 206, 224
programming of adult disease 118“119, 142
exogenous corticosterone 206
programming the heart 151
hemodynamic stressors 226
pro-opiomelanocortin 24, 115, 185, 191, 212
negative-feedback 226“227
see also POMC
pre-proenkephalin gene 225
pro-pregnancy environment 75
PVHmp 206
prostaglandin
secretogogue gene transcription 218, 222,
fetal membrane 81
223, 226
in vitro 84
serotonin transporter 19
parturition in mammals 75
279 Index


syncytial cells 20, 23, 79
signal transduction mechanisms
syncytiotrophoblast cell 20, 24, 52, 54, 55
2-deoxyglucose (2-DG) 214
synthetic glucocorticoid
CRE-binding protein (CREB) 213
betamethasone 119, 121“123, 127, 147,
CREB-binding protein (CBP) 213
149, 152, 158, 161, 166, 238
mitogen-activated protein (MAP) 214
dexamethasone 121“123, 125, 126, 145,
protein kinase (PK) 213
147, 149“150, 152, 158“162, 238
social phobia 257
sociodemographic characteristics 186“187
temperamental shyness 250, 259
solitary nucleus 10, 245
time domains 212, 216
somatogenic 102
timing of birth in humans
Southern blot hybridization 43
biochemical markers 78
spatial domains 216
gestational length 79
spinal cord 208, 209
transgenic mice 127, 153, 163, 164
steroid production 2, 92, 127, 149, 154
transport
steroidogenesis 24, 99, 104
amino acid 101
stress hormones
calcium 45, 46
ACTH 8, 20, 30, 81, 96, 115, 120, 183, 186,
CRH 238
203, 218
glucose 127, 152
cortisol 2, 8, 29, 47, 92, 100, 115, 129, 146,
intracellular 91
185
monoamine 19
placental CRH 6, 21, 30, 47, 84, 94, 185, 189
receptor 155
-endorphin ( E) 183, 185, 186, 191
tumour necrosis factor alpha (TNF ) 26, 52,
stress types
144
pathological stress 19
type 2 diabetes 5, 91, 114, 118, 126, 127, 131,
physiological stress 35, 184, 195
142, 143, 146, 156
postnatal stress 194
prenatal stress 118, 159, 162, 183, 194
ultrasonography 186
psychosocial stress 8, 91, 185, 195, 241, 258
umbilical cord plasma 21, 33, 40, 45
stress
umbilical venous plasma 21
homeostatic motor events 221
uncoupling proteins (UCP) 152
hypotension or hypoglycemia 221
undernutrition 5, 90, 107, 108, 125, 127, 144,
peptide synthetic mechanisms 222
149, 154, 159
PVH neuroendocrine peptide gene
urocortin 20, 21, 23, 24, 25, 48
expression 221
U-shaped curve 91, 107
stria terminalis 8, 9, 11, 92, 215, 243, 245,
uterine contraction 28, 33, 37, 46, 88, 191
246, 248, 249, 250, 258
utero-placental blood flow 47
structural compartmentalization
magnocellular motor neurons 209
vaginal delivery 27, 33, 39, 40, 41, 43
neuroendocrine motor neurons 208
vibroacoustic 186, 191
parvicellular pre-autonomic neurons 208,
visceral adiposity
209
vulnerability to affective disorders 254
structural effects of antenatal glucocorticoids
on the CNS 160
zona fasciculata 115, 116
subtraction hybridization 83
zona glomerulosa 116
suprachiasmatic nucleus (SCH) 206, 218, 221
zoonosis factor 104
sustained hypovolemia 222, 223, 224, 226

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